PHARMALIEGE

  The US FDA granted approval to Eli Lilly’s Lyumjev™ (insulin lispro-aabc injection, 100 units/mL and 200 units/mL). This is a new rapid fast-acting insulin with a novel formulation to speed up the absorption of insulin into the blood stream and reduce glucose levels post meals, mimicking natural insulin’s post prandial action. Eli Lilly has another fast-acting insulin Humalog™ in the market. In comparative studies, Lyumjev™ has demonstrated faster absorption profile compared to Humalog™. The rapid insulin time-action profile can be attributed to two excipients in the formulation: microdose of treprostinil which increases absorption through vasodilation and sodium citrate which increases local vascular permeability. The approval of the drug was based on two phase 3 studies: PRONTO T1D and PRONTO T2D. In both studies Lyumjev™ demonstrated superior action compared to Humalog in preventing blood glucose spikes one and two hours after meal. Earlier this year, the product was approved ...

 A recent study by All India Institute of Medical Science (AIIMS) claimed that the presence of Delta variant is predominantly found even after getting a single dose or both doses of Covid-19 vaccine. According to some experts, both doses of the Covid-19 vaccines are needed for strong protection against the Delta variant. A highly transmissible variant of the coronavirus disease (Covid-19) is now rapidly spreading across the globe, causing more stringent control in some countries and derailing lockdown plans of others. The Delta variant, first detected in India, has been listed as 'variant of concern' by the World Health Organization (WHO). Here's how the Delta variant is affecting the world: The Zimbabwean government on Saturday announced a two-week localised lockdown for Hurungwe and Kariba districts after detecting the Delta variant of Covid-19. The government said that more than 40 cases were recorded in the last three days. The UK government is considering a delay of up...

As the number of coronavirus cases in the country subsides, government officials continue to encourage people to take their vaccine shots as soon as possible. While people are still sceptical and have their own reservations about vaccine efficacy, experts believe that it is the only possible way we can curb the impact of the pandemic. On the other hand, the growing number of variants has also become a cause of concern. The Delta Variant, which was originally detected in India in October last year, is said to be highly infectious. According to separate studies conducted by AIIMS (Delhi) and the National Centre for Disease Control (NCDC), it was suggested that the Delta variant can escape antibodies from one or both the doses of Covidshield and Covaxin. 1)What is the Delta Variant? -The Delta variant, scientifically termed as B.1.617.2 of the COVID-19 infections, refers to the merging of two mutations of a virus strain that go on to form a third, super infectious strain. The B.1.617 vari...

  The accident occurred at a factory called Nobel Intermediates Pvt in Shirgaon MIDC's Aptewadi area around 10:22 p.m.   A gas leak on Thursday night, from a chemical factory in Maharashtra's Badlapur, was reported, causing panic among the locals. Several residents within three kilometers complained about difficulty breathing and eye irritation.   A few people were admitted to local hospitals as a precaution. They were discharged after seeking medical assistance. The fire brigade hurried to the plant as soon as the incident was reported and controlled the situation. The leakage was stopped at about 11:24 p.m. The officials said that no casualties were reported.  According to the Thane Municipal Corporation, the incident occurred due to a chemical reaction caused by the overheating of sulfuric acid and benzyl acid. The police warned locals to stay indoors for a couple of hours.  The situation, according to officials, is under control now. 

  China has reported the first case of human infection with the H10N3 strain of bird flu from the country’s eastern Jiangsu province, China’s National Health Commission said on Tuesday. The patient, a 41-year-old man from Zhenjiang city, is currently in a stable condition and meets discharge standards, the state-run CGTN TV reported. Health authorities played down the outbreak, saying the case was a sporadic virus transmission from poultry to humans, and the risk of causing a pandemic was extremely low. The patient was diagnosed as having the H10N3 avian influenza virus on May 28, National Health Commission said in a statement without elaborating on how the man had got infected with the virus. No other cases of human infection with H10N3 have previously been reported globally, H10N3 is a low pathogenic or relatively less severe strain of the virus in poultry and the risk of it spreading on a large scale is very low. There are many different strains of avian influenza in Chi...

  After the therapy was approved in India earlier this month, CIMS Hospital became the first private facility in Gujarat’s Ahmedabad to administer an antibody cocktail to a Covid-19 patient. The monoclonal antibody cocktail treatment was launched in India just last week for treating mild Covid-19 patients. A 38-year-old diabetic male patient with Covid-19 symptoms were administered the antibody cocktail of Casirivimab and Imdevimab . CIMS is the first hospital in Ahmedabad to begin this treatment. According to Doctors, the cocktail treatment is recommended only in the early stages of the Covid-19 infection and for high-risk patients. It is the same treatment that former US President Donald Trump received last year. The patient we administered the combination medication today has diabetes and hence belongs to the high-risk group. The high mortality in young males during the second wave has been a grave concern for the medical fraternity. This medication is not recommended fo...

India’s healthcare system has been battling various issues, including the low number of institutions and less-than-adequate human resources for quite a while now. Essentially, a three-tier structure defined the Indian healthcare system- primary, secondary, and tertiary care services. The Indian Public Health Standards (IPHS) states that the delivery of primary healthcare is provided to the rural population through sub-center, primary health center (PHC), and community health center (CHC), while secondary care is delivered through district and sub-district hospitals. On the other hand, tertiary care is extended at regional/central level institutions or super-specialty hospitals. While there is an urgency to focus on all the three levels of primary, secondary and tertiary healthcare, it is imperative that the government look towards improving primary healthcare as a public good. Reasons of struggling India’s healthcare system: Lack of infrastructure. Shortage of efficient and trained...

The rising cases of Black Fungus infection in several states of India, four cases of White Fungus infection have been reported from Patna in Bihar. It is to be noted that White Fungus is considered more dangerous than Black Fungus. As the central government asks states to notify black fungus or mucormycosis an epidemic, an infection called white fungus has also been found to affect some people. White Fungus infection is more dangerous than black fungus infection because it affects lungs as well as other parts of the body including nails, skin, stomach, kidney, brain, private parts and mouth. White fungus also infects the lungs and an infection similar to COVID-19 is detected when HRCT is performed on the infected patient. Causes of White Fungus: This infection can be caused due to low immunity, or if people come in contact with things that contain these moulds like water, etc. Thus, sanitation is important to prevent this infection. Risk factors: COVID-19 patients are more pr...

An anti-COVID-19 therapeutic application of the drug 2-deoxy-D-glucose (2-DG) has been developed by the Institute of Nuclear Medicine and Allied Sciences (INMAS), a lab of Defence Research and Development Organization (DRDO), in collaboration with Dr Reddy’s Laboratories (DRL), Hyderabad. Clinical trial results have shown that this molecule helps in faster recovery of hospitalized patients and reduces supplemental oxygen dependence.   Phase-I Trial: In April 2020 , during the first wave of the pandemic, INMAS-DRDO scientists conducted laboratory experiments with the help of Centre for Cellular and Molecular Biology (CCMB) and found that this molecule works effectively against the SARS-CoV-2 virus and inhibits viral growth. Based on these results, DCGI and CDSCO permitted  Phase-II clinical trial of 2-DG in COVID-19 ppatients in May 2020.   Phase-II Trial: In Phase-II trials conducted during May to October 2020 , the drug was found to be safe in COVID-19 patients ...

  ·        Covid-19 Vaccines: Manufacturing company /Institute Name of Vaccine SSI Covishield(Chimpanzee adenovirus) Bharat biotech Covaxin(Inactivated virus) Zydus Cadila ZycoV-D (Plasmid DNA vaccine) Hetero biopharma SputnikV(cold type of virus) Dr.Reddys laboratories Sputnik V (cold type of virus) Panacea Biotech Covaxin(Inactivated virus) German company CVnCoV(mRNA-based vaccine) Geneva HGCO19(mRNA-based vaccine) Oxford University AstraZeneca (adenovirus) China’s Wuhan institute Sinopharm,Sinovac(Inactivated virus) Sinovac biotech Ltd Chinese company Coronavac (Inactivated virus) US national institute Moderna (mRNA-based vacc...

  Nowadays Mucormycosis (Black fungal disease) is infected peoples with COVID-19. It is a fungal infection that occurs by mold  mucormycetes . It enters from the nose then transfer to the eyes and then the brain when the infection is in the brain then it is deadly so in this condition, the eye is removed by surgery. Firstly, in Ahmednagar patients found which are infected by this black fungus, in the last 15 days, 40 patients found in Surat and 6 patients in 2 days in Delhi which are suffering from Mucormycosis. Risk Factor: 1.       Diabetic ketoacidosis. 2.       Increase Iron load. 3.       End stage renal disease. 4.       Patient taking Iron therapy. 5.       Defect in phagocytic function. Symptom: 1.       Nasal obstruction. 2.       Bloody nasal discharge. 3.       Facial pain. 4. ...

COVID-19 is now again spread rapidly in India and in the second phase virus gets mutant and affects lots of population. The numbers of confirmed cases are rapidly increasing day by day. Below are the top 10 states which contribute the total 78% of total confirmed cases from India. Sr. No. STATE CONFIRMED ACTIVE RECOVERED DECREASED 1 Maharashtra 37,03,584 6,38,034 30,04,391 59,551 2 Kerala 12,07,333 69,865 11,32,267 4,878 3 Karnataka 11,24,509 1,07,315 10,03,985 13,190 4 Tamil Nadu 9,71,384 61,593 8,96,759 13,032 5 Andhra Pradesh 9,48,231 35,592 9,05,266 7,373 6 Delhi 8,03,623 61,005 7,30,825 ...